Acid-base titrimetric assay of hydroxyzine dihydrochloride in pharmaceutical samples

Acid-base Titrimetric Assay of Hydroxyzine Dihydrochloride in Pharmaceutical Samples

Two simple titrimetric methods have been developed for the determination of hydroxyzine dihydrochloride (HDH) in pure form and in tablets. The principle of the methods are simple acid-base reactions in which the hydrochloride content of the drug was determined by titrating with an aqueous standardized NaOH solution either visually using phenolphthalein as indicator (method A) or potentiometrica...

Titrimetric Assay of Hydroxyzine Dihydrochloride in Pharmaceuticals and Formulations in Non-aqueous Medium

Hydroxyzine, a piperazine H1-receptor antagonists effective in generalized anxiety disorder. Two simple, rapid, reliable, precise and accurate and cost-effective non-aqueous titrimetric procedures have been developed for the determination of hydroxyzine dihydrochloride (HDH) in bulk drug and its pharmaceutical formulations. The methods are based on the titration of the drug in glacial acetic ac...

Acid-base titrimetric assay of pheniramine maleate in pharmaceuticals in hydro-alcoholic medium

Two simple titrimetric methods are described for the determination of pheniramine maleate (PAM) in pure form and in its dosage forms. The principle involved in the methods are simple acid-base reaction in which the carboxylic acid group of the drug was determined by titrating with an aqueous NaOH solution either visually using phenolphthalein as indicator (method A) or pH-metrically (method B) ...

Investigation and Optimization of Titrimetric and Spectrophotometric Methods for the Assay of Flunarizine Dihydrochloride Using in Situ Bromine.

Three indirect methods for the assay of flunarizine dihydrochloride (FNH) in bulk drug and commercial formulation based on titrimetric and spectrophotometric techniques using bromate-bromide mixture are described. In titrimetry, a measured excess of bromate-bromide mixture is added to an acidified solution of FNH and the unreacted bromine is determined iodometrically (method A). Spectrophotomet...

Titrimetric, Spectrophotometric and Chromatographic Assay of Ofloxacin